15:00 Registration opens 19:00-20:00 Dinner 20:00-20:45 OPENING REMARKS Lipid-protein homeostasis of cells: thermomechanical basis of lipid and protein sorting among cellular organelles Erick Sackmann, Ludwig-Maximilians-Universitat München, Germany 20:45-21:30 Speed Networking 21:30 Get together and poster viewing

07:00-10:00 Early morning optional activity in the Dead Sea area 11:00-13:00 Session 1: LIPID MEMBRANES I Chair: Avinaom Ben-Shaul, The Hebrew University of Jerusalem, Israel 11:00-11:30 Mechanisms of shaping membrane nanostructures of Endoplasmic Reticulum Michael Kozlov Tel Aviv University, Israel 11:30-12:00 Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction Patricia Bassereau Institut Curie, France 12:00-12:30 New wine in old bottles: Fusogenic liposomes studied with classical techniques of membrane biophysics Rudolf Merkel Forschungszentrum Julich, Germany 12:30-12:50 Membrane remodeling in migrasome formation Raya Sorkin Tel Aviv University, Israel 12:50-13:00 Discussion 13:00 Light Lunch 14:00-15:40 Session 2: LIPID MEMBRANES II Chair: Avinoam Ben-Shaul The Hebrew University of Jerusalem, Israel 14:00-14:30 100 years after the Poisson-Boltzmann theory for charged membranes: What's new David Andelman, Tel Aviv University, Israel 14:30-15:00 Elasticity of inhomogeneous lipid membranes Daniel Harries, The Hebrew University of Jerusalem, Israel 15:00-15:30 Biomechanics in the regulation of immune cell activation Anna Suncana Smith, Friedrich-Alexander University Erlangen, Germany 15:30-15:40 Discussion 15:40-16:30 Coffee Break and Discussion Time 16:30-19:00 Session 3: ACTIVE CYTOSKELETON NETWORKS Chair: Rhoda Hawkins, University of Sheffield, UK 16:30-17:00 Active cytoskeletal materials design their own shape Anne Bernheim-Groswasser, Ben Gurion University of the Negev, Israel 17:00-17:30 Self-organization of actomyosin networks with turnover Kinneret Keren, Technion – Israel Institute of Technology, Israel 17:30-18:00 Modelling non-muscle myosin II minifilaments Ulrich Schwarz, Univeristy of Heidelberg, Germany 18:00-18:20 "Cell division" in vitro: how self-organizing molecular motors drive shape change in liquid crystal droplets comprising cytoskeletal filaments Kinjal Dasbiswas University of California Merced, California, USA 18:20-18:30 Discussion 18:30-19:00 Poster flash talks 19:00-20:15 Dinner 20:15 POSTER SESSION

08:00-11:00 Session 4: CYTOSKELETON MECHANICS Chair: Ayelet Lesman, Tel Aviv University, Israel 08:00-08:30 Cytoskeleton structure and dynamics - what does it tell us about cell mechanics Florian Rehfeldt, Universitat Bayreuth, Germany 08:30-09:00 Cytoskeletal filament mechanics across scales: from molecular interactions to filament stretching Sarah Köster, University of Göttingen, Germany 09:00-09:30 How actin dynamics shape tubular membranes Cecile Sykes CNRS and Ecole Normale Supérieure, France 09:30-09:50 Viewing multi-microtubule array destruction through an AFM lens Radhika Subramanian Harvard Medical School, and Massachusetts General Hospital, USA 09:50-10:10 Cell volume regulation and the cytoskeleton Sean Sun Johns Hopkins University, USA 10:10-10:25 Actin cortex mechanics probed in live cells Joseph Vermeil Institute Curie, France 10:25-10:40 Membrane fluidity regulates cortical mechanics by limiting myosin mediated actin remodelling and increasing tension Srishti Dar EMBL, Germany 10:40-11:00 Discussion 11:00-11:30 Coffee Break and Discussion Time 11:30-14:30 Session 5: CELL AND TISSUE MECHANICS I Chair: Assaf Zemel, The Hebrew University of Jerusalem, Israel 11:30-12:00 Fracture in living tissues Guillaume Charras, University College London, UK 12:00-12:30 The chemo-mechanical regulation of neuronal growth in the developing brain Kristian Franze, Friedrich-Alexander University Erlangen, Germany 12:30-13:00 Can mechanotyping help predict the metastatic potential of cancer cells? Ben Fabry Friedrich-Alexander University Erlangen, Germany 13:00-13:20 Skin epithelial cells change their mechanics and proliferation upon snail-mediated EMT signalling Elisabeth Fischer-Friedrich Technische Universität Dresden, Germany 13:20-13:35 Disentangling the role of rheology in predicting tissue fracture Alessandra Bonfanti Politecnico di Milano, Italy 13:35-13:55 Discussion 13:55-14:30 Poster flash talks 15:00-19:30 EXCURSION to Jerusalem+Dinner 20:30 POSTER SESSION

09:00-11:00 Session 6: MECHANICS OF THE NUCLEUS AND CHROMATIN Chair: Shelly Tzill, Technion- Israel Institute of Technology, Israel 09:00-09:30 Chromatin transactions - one molecule at a time Ariel Kaplan, Technion – Israel Institute of Technology, Israel 09:30-10:00 Nuclear curvature and rupture: small lipid droplets are rigid and dangerous Dennis Discher, University of Pennsylvania, USA 10:00-10:30 Soft nuclear physics of cells Samuel Safran, Weizmann Institute of Science, Israel 10:30-10:50 Intranuclear herpes DNA ejection induces robust mechanoprotection of nucleus integrity required for viral genome replication Alex Evilevitch Lund University, Sweden 10:50-11:00 Discussion 11:00-11:50 Coffee Break 11:50-13:45 Session 7: CELL ADHESION AND MIGRATION Chair: Franziska Lautenschlager, University of the Saarland, Germany 11:50-12:20 The manifold of integrin-mediated adhesions in an interplay with microtubules and myosin filaments Alexander Bershadsky, National University of Singapore, Singapore and Weizmann Institute of Science, Israel 12:20-12:50 Cellular morphodynamics on single cell microarrays - matching statistics to mechanisms Joachim Radler, Ludwig-Maximilians-Universitat Munchen, Germany 12:50-13:05 An external, long-lived memory in cell migration based on retroactions with the substrate Joseph D'Alessandro CNRS, France 13:05-13:20 Active-gel theory for multicellular migration in the extra-cellular matrix Ram Adar, Institut Curie, France 13:20-13:35 Effect of environment heterogeneity on collective behavior of migrating cells Zuzana Dunajova Institute of Science and Technology Austria (ISTA), Austria 13:35-13:45 Discussion 13:45-14:40 Light lunch 14:40-17:20 Session 8: CELL MECHANICS Chair: Shelly Tzill, Technion- Israel Institute of Technology, Israel 14:40-15:10 Engineering the shape and mechanics of epithelial sheets Xavier Trepat, Institute for Bioengineering of Catalonia (IBEC), Spain 15:10-15:40 Revisiting vimentin intermediate filaments in cells David Weitz, Harvard University, USA 15:40-16:10 Machine Learning Continuum Models of Adherent Cells Margaret Gardel, University of Chicago, USA 16:10-16:40 Emergence of order from randomness in multi-cellular systems through long range cell-cell interactions Taher Saif, University of Illinois at Urbana-Champaign, USA 16:40-16:55 Mechanical communication in cardiac cell beating Ido Nitsan, Technion - Israel Institute of Technology, Haifa, Israel 16:55-17:10 Probing local force propagation in tensed fibrous gels Shahar Goren Tel Aviv University, Israel 17:10-17:20 Discussion 17:20-18:15 Coffee Break and Discussion Time SATELLITE: IMPLICATIONS FOR CANCER AND DEVELOPMENT 18:15-20:00 Session 9: PHYSICS OF CANCER Chair: TBA 18:15-18:45 Cells in a tight spot: learning the dynamics and interactions in confined cell migration Chase P. Broedersz, Ludwig-Maximilians-Universitat Munchen, Germany 18:45-19:05 Physical properties of 3D matrix regulate killing efficiency of cytotoxic T cells Bin Qu, Saarland University, Germany 19:05-19:25 Critical slowing down and developmental robustness David Bensimon, ENS, France 19:25-19:45 Fibroblasts deposit membranous tracks that steer cancer cell migration Francesco Baschieri, Université Paris-Saclay, France 19:45-20:00 Cell communication in cancer Mirna Elizabeta Kramar, Institut Curie, France 20:00-20:15 Brain storming for the next conference - topics and organizers 20:15 Farewell Dinner and Conference Party

09:00-10:20 Session 10: TISSUES AND DEVELOPMENT Chair: David Sprinzak 09:00-09:30 Collective mechanisms for cell motility in monolayers and stratified epithelia Lisa Manning, Syracuse University, USA 09:30-10:00 Physics of Living Matter: From Molecule to Embryo Sebastian Streichan, UC Santa Barbara, USA 10:00-10:20 A mechanochemical model recapitulates distinct vertebrate gastrulation modes Mattia Serra UC San Diego, USA 10:20-10:50 Coffee Break and Discussion Time 10:50-12:00 Session 11: TISSUES AND DEVELOPMENT II Chair: David Sprinzak 10:50-11:10 Floral patterns in multi-strain bacterial colonies Lev Tsimring, UC San Diego, USA 11:10-11:25 Observation of topological action potentials in engineered tissues Hillel Ori Harvard University, USA 11:25-11:40 Genetic and geometric heredity interact to drive polarized flow in the Drosophila embryo Bandan Chakrabortty Aix-Marseille University, France 11:40-12:00 Directed cell invasion and asymmetric adhesion drive tissue elongation and turning in C. elegans gonad morphogenesis Ronen Zaidel-Bar Tel Aviv University, Israel 12:00 Concluding remarks and departure